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The difference between sublingual immunotherapy and allergy shots

Manan Shah, MD, ENT

Wyndly co-founder & Chief Medical Officer. Dedicated to personalizing care and making allergies a thing of the past.

Updated on Nov 17, 2021


This article is a transcript.

What's the difference between sublingual immunotherapy known as allergy drops or allergy tablets and allergy shots? I'm Dr. Manan Shah. I'm an ENT and allergist with Wyndly Health. Immunotherapy is the only way that you can change your immune system for longterm allergy relief. And there's two ways of doing this.

The traditional method was allergy shots, which is where you came to my office and you got a weekly injection. Allergy shots were great for things like environmental allergens and also bee stings. But about 30 years ago, they discovered another technology called sublingual immunotherapy, which is where you take the allergen under your mouth.

This is great because you can do it at home. You don't need any doctor's visits and you don't need any weekly shots. Some of the benefits of sublingual immunotherapy is that they appear to be safer in clinical trials. They've been shown in research work just as well as allergy shots, and they can be done at home.

Ultimately, what you want to do is work with your doctor to figure out what works best for your life and pick that therapy. If you'd like to learn more, let me know.


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