**Alternatives to Allergy Shots: Sublingual Immunotherapy and More**
What Are the Main Alternatives to Allergy Shots?
The main alternatives to allergy shots include sublingual immunotherapy, allergy medications, environmental controls, and natural remedies. Each option offers different benefits and may work better for certain individuals depending on their specific allergies, lifestyle, and treatment preferences.
Sublingual Immunotherapy
Sublingual immunotherapy involves placing allergy drops or tablets under the tongue to build tolerance to allergens over time. This treatment works similarly to allergy shots by gradually desensitizing your immune system, but without the needles or frequent doctor visits. Available as both custom-formulated drops and FDA-approved tablets, sublingual immunotherapy can treat various environmental allergies including pollen, dust mites, and pet dander.
Allergy Medications
Over-the-counter (OTC) and prescription allergy medications provide symptom relief through different mechanisms. Common medication types include: • Antihistamines (cetirizine, loratadine, fexofenadine) - block histamine to reduce sneezing, itching, and runny nose • Nasal corticosteroids (fluticasone, mometasone) - reduce inflammation in nasal passages • Decongestants (pseudoephedrine) - relieve nasal congestion • Leukotriene modifiers (montelukast) - block inflammatory chemicals
Environmental Controls
Reducing exposure to allergens through environmental modifications can significantly decrease symptoms without medication. Key strategies include: • Using HEPA filters in air purifiers and vacuum cleaners • Keeping windows closed during high pollen days • Washing bedding weekly in hot water • Removing carpets and using allergen-proof mattress covers • Maintaining indoor humidity below 50% to prevent mold growth
Natural Remedies
Natural approaches can complement other treatments or provide mild symptom relief for some individuals. Saline nasal rinses help flush allergens from nasal passages, while local honey may help with pollen allergies when consumed regularly. Quercetin supplements, butterbur extract, and acupuncture have shown promise in some studies, though scientific evidence varies for these remedies.
What Is Sublingual Immunotherapy?
Sublingual immunotherapy is a form of allergy treatment that involves placing allergen extracts under the tongue to build tolerance over time. This method works by gradually training your immune system to stop overreacting to specific allergens, providing long-term relief without needles or frequent clinic visits.
How Sublingual Immunotherapy Works
The treatment introduces small, controlled amounts of allergens to your immune system through the tissues under your tongue. These tissues contain specialized cells that help modify your immune response, gradually reducing sensitivity to allergens over months of consistent treatment. Unlike medications that only mask symptoms, sublingual immunotherapy addresses the root cause by retraining your immune system's response.
Sublingual Allergy Drops
Sublingual allergy drops are custom-formulated liquid treatments tailored to your specific allergen sensitivities based on allergy testing results. Patients typically place drops under the tongue daily at home, holding them for 30-60 seconds before swallowing. Studies show allergy drops are just as effective as allergy shots while offering greater convenience and flexibility for treatment.
The drops can treat multiple allergens simultaneously, including pollen, dust mites, pet dander, and mold. Treatment usually continues for 3-5 years to achieve lasting immunity, though many patients notice symptom improvement within the first few months.
Sublingual Allergy Tablets
FDA-approved sublingual tablets target specific allergens like grass pollen, ragweed, and dust mites through standardized doses. These tablets dissolve quickly under the tongue and are taken daily during or before allergy season, depending on the specific product. Available options include Grastek (Timothy grass), Ragwitek (ragweed), and Odactra (dust mites).
While tablets offer the convenience of pre-measured doses, they're limited to treating single allergens at a time. Patients with multiple allergies may need several different tablets or might find custom allergy drops more practical for comprehensive treatment.
How Do Sublingual Allergy Drops Compare to Allergy Shots?
Sublingual allergy drops compare favorably to allergy shots in effectiveness while offering superior convenience, safety, and often better cost value. Both treatments provide long-term relief through immunotherapy, but drops eliminate the need for frequent clinic visits and have a lower risk of severe allergic reactions than injections.
Effectiveness
Research demonstrates that sublingual immunotherapy achieves similar success rates to allergy shots, with both treatments reducing symptoms by 30-60% in most patients. Clinical studies comparing allergy drops to shots show comparable improvements in quality of life and reduction in medication use. The key difference lies in treatment adherence, where drops often see better completion rates due to their convenience.
Convenience
Sublingual drops offer significant advantages over the traditional injection schedule required for shots. Patients can self-administer drops at home daily, eliminating the need for weekly or bi-weekly clinic visits that shots require during the build-up phase. This flexibility makes drops particularly appealing for busy adults, parents with children, or those living far from allergy clinics.
Safety Profile
The safety record of sublingual immunotherapy surpasses that of allergy shots, which carry risks including severe allergic reactions. Drops rarely cause systemic reactions, with most side effects limited to mild oral itching or tingling that typically resolves within days. This improved safety profile allows drops to be taken at home without medical supervision, unlike shots which require a 30-minute observation period after each injection.
Cost Considerations
While insurance coverage varies, sublingual drops often prove more economical when factoring in indirect costs. Allergy shots for adults require frequent office visits, resulting in lost work time, transportation expenses, and copays that add up over years of treatment. Drops eliminate these hidden costs, and many patients find the overall expense comparable or lower than shots when considering the full treatment duration.
What Is the Difference Between Sublingual Allergy Drops and Tablets?
The main difference between sublingual allergy drops and tablets lies in their formulation, allergen coverage, and customization options. Drops are liquid formulations that can be personalized for multiple allergens, while tablets are FDA-approved solid forms that typically target single allergen types like grass or ragweed pollen.
Key Differences in Formulation and Coverage
Sublingual drops offer several distinct advantages: • Custom-mixed formulations targeting multiple allergens simultaneously • Flexible dosing that can be adjusted based on patient response • Treatment for a broader range of allergens including foods, molds, and animal dander • Compounded specifically for each patient's skin allergy test results
Sublingual tablets have their own characteristics: • FDA-approved for specific allergens (grass, ragweed, dust mites) • Standardized doses with consistent allergen content • Limited to treating one allergen type per tablet • Available by prescription at most pharmacies
Practical Considerations for Patients
Drops provide greater flexibility for patients with multiple allergies, as one bottle can address various sensitivities without needing multiple medications. Tablets work well for patients with single, dominant allergies who prefer FDA-approved options with established insurance coverage. Both forms dissolve under the tongue and avoid the drowsiness associated with non-drowsy allergy medicines, offering long-term relief rather than temporary symptom management.
Who Can Benefit From Sublingual Immunotherapy?
People who can benefit from sublingual immunotherapy include those with environmental allergies, needle phobia, busy schedules, or limited access to allergy clinics. This treatment particularly suits patients seeking convenient, at-home allergy management without weekly injections or frequent doctor visits for shot administration.
Ideal Candidates
The best candidates for sublingual immunotherapy are patients with confirmed IgE-mediated allergies who want long-term relief beyond symptom management. Ideal candidates include: • Adults and children with moderate to severe allergic rhinitis • Patients who haven't achieved adequate control with OTC medications • Individuals unable to commit to regular clinic visits for shots • People with needle anxiety or injection site reactions
Patients with multiple environmental allergies often see excellent results, as sublingual drops can address various allergens simultaneously. Those who travel frequently or live far from allergy clinics find this home-based treatment particularly valuable.
Age Considerations
Sublingual immunotherapy can be safely administered to patients as young as 5 years old, making it an excellent alternative for children who fear needles. Adults of any age can use this treatment, including elderly patients who may have difficulty traveling to appointments. The treatment's safety profile allows for use in patients who might not be candidates for traditional shots due to age-related health concerns.
Allergy Types Treated
Sublingual immunotherapy effectively treats various environmental allergies including tree, grass, and weed pollens, dust mites, mold spores, and pet dander. Some formulations also address certain food allergies, though this requires specialized protocols. The treatment works best for airborne allergens that cause respiratory symptoms, making it ideal for seasonal and perennial allergic rhinitis sufferers seeking alternatives to allergy shots.
How Do I Take Sublingual Immunotherapy Drops?
You take sublingual immunotherapy drops by placing them under your tongue, holding for 30-90 seconds, then swallowing. The process takes just minutes daily and can be done at home without medical supervision after initial instruction from your healthcare provider.
Administration Method
Place the prescribed number of drops directly under your tongue using the provided dropper or dispenser. Key steps for proper administration: • Hold drops under the tongue for at least 30 seconds before swallowing • Avoid eating or drinking for 5 minutes after taking drops • Take drops at the same time each day for consistency • Store drops according to package instructions, typically refrigerated
The sublingual area has numerous blood vessels that absorb the allergen extracts directly into your bloodstream. This bypasses the digestive system, allowing for effective immune system exposure without injection.
Dosing Schedule
Most patients start with a build-up phase, taking drops once or twice daily with gradually increasing doses over several weeks. After reaching the maintenance dose, patients typically continue with once-daily administration. Missing occasional doses won't restart treatment, but consistency improves outcomes significantly.
Treatment Duration
Sublingual immunotherapy typically requires 3-5 years of consistent use for lasting results, similar to allergy shots. Initial symptom improvement often occurs within 3-6 months, with maximum benefits achieved after 1-2 years. Stopping treatment early may result in symptoms returning, though some patients maintain improvement even after discontinuation.
How Long Does Sublingual Immunotherapy Take to Work?
Sublingual immunotherapy typically begins showing initial improvements within 3-6 months, though some patients notice changes as early as 8-12 weeks. Full therapeutic benefits usually develop over 1-2 years of consistent treatment, with continued improvement throughout the recommended 3-5 year treatment course.
Timeline of expected improvements: • First 2-3 months: Subtle reduction in symptom severity • 3-6 months: Noticeable decrease in allergy medication use • 6-12 months: Significant symptom improvement during peak allergy seasons • 1-2 years: Maximum therapeutic benefit achieved • 3-5 years: Long-lasting immune tolerance established
Individual response times vary based on allergen sensitivity levels, treatment adherence, and the specific allergens being treated. Patients with multiple allergies may experience staggered improvement as their immune system adapts to different allergens at varying rates. Environmental allergen exposure during treatment can also influence how quickly patients perceive symptom relief.
What Are the Risks and Benefits of Alternative Immunotherapy?
Alternative immunotherapy offers significant benefits including convenience, safety, and effectiveness, while risks primarily involve mild local reactions. The treatment provides long-term allergy relief without frequent clinic visits, making it accessible for patients who cannot commit to traditional allergy shot schedules.
Benefits
Key advantages of sublingual immunotherapy include: • Home administration eliminates weekly clinic visits and time off work • Lower risk of severe reactions compared to injection therapy • Child-friendly option with no needles required • Travel flexibility with portable treatment doses • Comparable effectiveness to traditional allergy shots for many allergens
Cost savings accumulate over time through reduced medication needs and fewer doctor visits. Patients typically experience improved quality of life, better sleep, and increased productivity as symptoms diminish. The treatment's safety profile allows for administration to younger children, often starting at age 5.
Potential Side Effects
Most side effects remain mild and localized to the mouth area. Common reactions include tingling or itching under the tongue, mild mouth swelling, and throat irritation lasting 15-30 minutes after administration. These symptoms typically resolve within the first few weeks of treatment as the body adjusts.
Rare but possible reactions: • Mild gastrointestinal upset or nausea • Temporary worsening of allergy symptoms • Localized swelling of lips or tongue • Mild skin reactions or hives
Contraindications
Certain medical conditions and circumstances make sublingual immunotherapy unsuitable for some patients. Severe, uncontrolled asthma represents the primary contraindication due to increased risk of respiratory complications. Patients with eosinophilic esophagitis or oral inflammatory conditions should avoid this treatment method.
Additional contraindications include: • Active oral infections or open mouth sores • Recent oral surgery or dental procedures • Severe immune system disorders • Certain medications like beta-blockers • History of severe allergic reactions to immunotherapy
Live Allergy-Free with Wyndly
If you want long-term relief from your allergies, Wyndly can help. Our doctors will help you identify your allergy triggers and create a personalized treatment plan to get you the lifelong relief you deserve. Start by taking our quick online allergy assessment today!
Frequently Asked Questions
What is Taylor Swift allergic to?
Taylor Swift has publicly shared that she's allergic to cats, despite owning several of them. She's mentioned taking allergy medication to manage her symptoms. She has also stated she's allergic to lavender. These allergies haven't stopped her from living with her beloved pets.
Can an allergy shot cause diarrhea?
Allergy shots rarely cause diarrhea directly. Common side effects include redness or swelling at the injection site. However, severe allergic reactions (anaphylaxis) from shots can occasionally cause gastrointestinal symptoms including diarrhea, though this is uncommon. Contact your allergist if you experience persistent digestive issues after treatment.
What can you do instead of allergy shots?
Instead of allergy shots, you can try sublingual immunotherapy (allergy drops or tablets), antihistamines, nasal corticosteroid sprays, or decongestants. Other options include allergen avoidance, using HEPA filters, saline nasal rinses, and leukotriene modifiers. Consult an allergist to determine which alternative treatment best suits your specific allergy needs.
What do naturopaths recommend for allergies?
Naturopaths typically recommend quercetin supplements, stinging nettle, butterbur, and local honey for allergies. They often suggest dietary changes like eliminating dairy and processed foods, increasing omega-3 fatty acids, and using nasal irrigation with saline solution. Probiotics, vitamin C, and acupuncture are also common naturopathic allergy treatments.
How to naturally get rid of allergy symptoms?
Natural allergy relief includes using a saline nasal rinse to flush allergens, consuming local honey to build tolerance, taking quercetin supplements, and drinking green tea for antihistamines. Keep windows closed during high pollen days, shower after being outdoors, and use HEPA filters to reduce indoor allergens.
What is the best alternative to allergy shots?
Sublingual immunotherapy (SLIT) tablets or drops placed under the tongue are the best alternative to allergy shots. They offer similar effectiveness for treating environmental allergies, can be taken at home without needles, and have fewer severe reaction risks. FDA-approved options include tablets for grass, ragweed, and dust mite allergies.

